After completing the evaluation of aspartic acid and beta-alanine Cissus, I decided to turn my attention to more controversial things. Ligandrol is a natural choice.
Ligandrol or LGD-4033 is a selective androgen receptor modulator (SARM), discovered by Ligand Pharmaceuticals and currently developed by Viking Therapeutics , .
It sounds very technical, and it’s true! I’ll talk about what this means in the next section.
LGD has been developed to treat muscle exhausting symptoms such as aging, osteoporosis, muscular dystrophy and cancer.
Why is it important? For example, in the case of cancer, for example, the prevalence of muscle loss is between 20% and 70%, depending on the type of tumor and the criteria used to evaluate . Muscle atrophy, including skeletal muscle loss, is a symptom associated with cancer that begins in the early stages of cancer progression, affects the patient’s quality of life and is resistant to chemotherapy and survival .
In addition to its legitimate medical applications, it is also used as a drug that increases efficacy. In the field of fitness, LGD has become a free alternative to the side effects of steroids (such as testosterone) to increase muscle mass and athletic performance.
The drug is popular among athletes and professionals who are aware of the size of the muscles and body composition, including weightlifters, bodybuilders, models, athletes, athletes and strong people.
Recently, LGD has a lot of hype. Although it is not a steroid, Ligandrol recently made headlines, as athletes got bogged down by taking illegal performance boosters. The Florida crocodile defender Vigril found Ligandrol in his system during routine testing , .
Substances such as LGD, designed for therapeutic use, are often used by athletes as stimulants and / or used to improve the image. This created a market for counterfeit stimulants that may have poor quality medicines and, therefore, pose a threat to the health of consumers .
What is Ligandrol?
LGD-4033 is a non-steroidal selective androgen receptor modulator (SARM).
Androgen (from the Greek “andro” meaning male) is a compound (natural or synthetic) that regulates vertebrates (including humans) by binding to androgen receptors (special receptors on cells). Develop and maintain male characteristics. Androgens are usually steroid hormones.
Selective androgen receptor modulators (SARMs) are selective in target tissues in vivo. This means that he has a high
Ffinity binds to the androgen receptor. As “selective”, SARMS can be administered orally, but only to a specific target region (in this case) to the androgen receptor in the muscle.
There are many conditions that cause muscle loss. With age, we lose muscle mass and muscle strength, which is called “muscle contraction.” It is known that sarcopenia increases the risk of falls, fractures, physical disability and leads to a low quality of life and leads to significant health and economic consequences.
Similarly, many diseases, such as chronic obstructive pulmonary disease, muscular dystrophy, end-stage renal disease and certain cancers, are aggravated by loss of muscle mass and physical function, which can lead to mobility problems and disability ,  .
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Therefore, anabolic therapy is needed to combat muscle loss and body function, and to reduce the burden of disability of people suffering from muscle loss due to aging or illness . Among the various anabolic treatments being developed, androgens are the most distant in development .
It is widely believed that the administration of testosterone increases muscle mass and strength, but concerns about its potential adverse effects lead to the development of SARM, a new tissue-selective ligand for androgen receptors . SARM regulates the same anabolic pathway associated with the classical steroid androgen 8.
Over the past decade, a number of pharmaceutical efforts have been undertaken to develop nonsteroidal SARMs for the treatment of muscle atrophy and functional limitations associated with acute and chronic diseases and aging.
Over the past two decades, the SARM class has been the subject of many clinical studies8. LGD-4033 binds androgen receptors with high affinity and selectivity, ie, binds in a powerful and purposeful manner . It is expected that it will provide the therapeutic benefits of testosterone with increased safety, tolerability and acceptance of the patient.
How many studies?
A lot of research has been done on the effectiveness of SARM, but so far there have been few studies on LGD.
LGD-4033 demonstrates the desired efficacy in vivo in the measurement of skeletal muscle and bone in animal models of the disease. There is only one publication